AstraZeneca holds talks with US cancer drug developer in $400bn merger

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Bristol Myers Squibb tie-up would be one of biggest-ever pharma deals and create world’s fourth-largest drugmaker

Britain’s biggest drugmaker, AstraZeneca, is understood to be in discussions to take over its US rival Bristol Myers Squibb in a deal that would create a near-$400bn (£300bn) pharmaceutical group.

AstraZeneca, run by Pascal Soriot, its longtime chief executive, is the second-biggest listed company in the UK, with a market value of nearly £196bn before the news broke. BMS, headquartered in Princeton and known for its cancer treatments, is worth $133bn.

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